Email this article Sodium deoxyribonucleate effects on the status of cervical cancer patients after radiotherapy
- Authors: Kozina Y.V.1, Slepov E.V.1, Kashaeva O.V.2, Pavlenko A.Y.3,4, Zukov R.A.1,5
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Affiliations:
- A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
- A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
- Moscow University of Medicine Reaviz
- V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
- Issue: Vol 18, No 4 (2022)
- Pages: 93-98
- Section: UROLOGICAL COMPLICATIONS IN CANCER PATIENTS
- Published: 03.12.2022
- URL: https://oncourology.eco-vector.com/oncur/article/view/1670
- DOI: https://doi.org/10.17650/1726-9776-2022-18-4-93-98
- ID: 1670
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Abstract
Background. Apart from surgery and medications, radiation therapy is one of the main treatment methods for malignant tumors of the cervix. However, its use is associated with high incidence of urological complications. In addition, the need for long-term treatment, reduced level of patients’ quality of life promote the necessity to minimize the frequency of urological complications and justify search and study of the most adequate methods of their prevention.
Aim. To evaluate the effect of radioprotector sodium deoxyribonucleate on clinical characteristics and quality of life of patients with cervical cancer after radiation treatment.
Materials and methods. 80 patients with cervical cancer treated in A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary. Patients received chemoand radiotherapy with the 3D conformal radiotherapy method in combination with intracavity gamma therapy sources of high dose with subsequent application of radioprotector and without it.
Results. On the 3rd visit it was found that in patients with cervical cancer using a radioprotector, reduced red blood cells and flat epithelium cells content in the urine sediment, it may be due to the reparative and cytoprotective sodium deoxyribonucleate properties. In the assessment of the life quality after combined therapy completion with radioprotector, 60 % of patients’ responses to the health assessment questions of the last week differed from the comparison group. Undesirable phenomena associated with sodium deoxyribonucleate therapy not observed in cervical cancer patients during radiotherapy and subsequent observation period.
Conclusion. Conformal external beam radiation therapy in combination with long-term intramuscular administration of a radioprotector has advantages compared to 3D conformal radiation therapy. This method reduces the severity of post-radiation side effects, increases time to development of hematological toxicity in the context of combination chemoradiotherapy, and reduces urothelial damage caused by chemoradiotherapy.
Keywords
About the authors
Yu. V. Kozina
A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
ORCID iD: 0000-0001-8155-7668
16 1st Smolenskaya St., Krasnoyarsk 660133
Russian FederationE. V. Slepov
A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary
ORCID iD: 0000-0002-3787-3126
16 1st Smolenskaya St., Krasnoyarsk 660133
Russian FederationO. V. Kashaeva
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
ORCID iD: 0000-0001-9601-7373
Build. 1, 20 Delegatskaya St., Moscow 127473
Russian FederationA. Yu. Pavlenko
Moscow University of Medicine Reaviz;
Build. 2, 2 Krasnobogatyrskaya St., Moscow 107564
Russian FederationR. A. Zukov
A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary;V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: zukov_rus@mail.ru
ORCID iD: 0000-0002-7210-3020
Ruslan Aleksandrovich Zukov
16 1st Smolenskaya St., Krasnoyarsk 660133;
1 Partizana Zheleznyaka St., Krasnoyarsk 660022
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