A modern view on thermoradiotherapy in integrative treatment of prostate cancer

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Abstract

Background. The article presents an overview of literature data on integrative treatment of prostate cancer using local hyperthermia.

Aim. To analyze modern Russian and foreign studies on the use of local hyperthermia in integrative treatment of prostate cancer and its long-term treatment results.

Materials and methods. The search for relevant sources was performed using the PubMed, eLIBRARY databases (publications from 2008 to 2023 were included) with key words “prostate cancer”, “local hyperthermia”, “radiation therapy”. For analysis of radiobiological aspects, sources published since 2004 were considered.

Results. A review of the literature data shows that of all the methods related to physical modifications through radiation, local hyperthermia is considered to be the most promising. Analysis of randomized studies on the use of local hyperthermia in integrative treatment of prostate cancer published by foreign and Russian researchers showed immediate and long-term results demonstrating the positive effect of thermoradiotherapy.

Conclusion. The combination of local hyperthermia and radiation therapy seems to be an innovative strategy to improve tumor control and increase the effectiveness of treatment. However, there are currently no data on the use of thermoradiotherapy using new irradiation techniques, such as intensity-modulated radiation therapy (IMRT), volumetric modulated radiation therapy (VMAT) which utilize modern linear accelerators. There is also no consensus on the use of thermoradiomodification in relation to the amount of exposure to the prostate, and therefore further research is required.

About the authors

E. V. Efanova

Novosibirsk State Medical University, Ministry of Health of Russia;
Novosibirsk Regional Clinical Oncology Dispensary

Email: misscathy@list.ru
ORCID iD: 0009-0008-2280-1198
SPIN-code: 6365-3171

52 Krasny Prospekt, Novosibirsk 630091; 
2 Plakhotnogo St., Novosibirsk 630108

Russian Federation

Zh. A. Startseva

Cancer Research Institute – branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: zhanna.alex@rambler.ru
ORCID iD: 0000-0002-4345-7719
SPIN-code: 8121-0310

5 Cooperativny Pereulok, Tomsk 634009

Russian Federation

S. A. Fursov

Novosibirsk State Medical University, Ministry of Health of Russia;
Novosibirsk Regional Clinical Oncology Dispensary

Email: safursov@mznso.ru
ORCID iD: 0009-0004-1637-256X
SPIN-code: 9714-0875

52 Krasny Prospekt, Novosibirsk 630091; 
2 Plakhotnogo St., Novosibirsk 630108

Russian Federation

A. L. Chernyshova

Novosibirsk State Medical University, Ministry of Health of Russia;
E.N. Meshalkin National Medical Research Center, Ministry of Health of Russia

Email: alacher@list.ru
ORCID iD: 0000-0002-8194-2811
SPIN-code: 2522-7513

52 Krasny Prospekt, Novosibirsk 63009;
115 Rechkunovskaya St., Novosibirsk 630055

Russian Federation

O. A. Tkachuk

Novosibirsk State Medical University, Ministry of Health of Russia;
Novosibirsk Regional Clinical Oncology Dispensary

Email: naiz@rambler.ru
ORCID iD: 0000-0002-6006-7093

52 Krasny Prospekt, Novosibirsk 630091; 
2 Plakhotnogo St., Novosibirsk 630108

Russian Federation

A. A. Chernyakov

Cancer Research Institute – branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Author for correspondence.
Email: a.cherniackow@yandex.ru
ORCID iD: 0000-0003-0829-0340
SPIN-code: 6269-5998

Aleksandr Alekseevich Chernyakov 

5 Cooperativny Pereulok, Tomsk 634009

Russian Federation

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