<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1947</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2025-21-3-136-141</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL NOTES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Prostate cancer metastasis to the stomach wall: a case report and literature review</article-title><trans-title-group xml:lang="ru"><trans-title>Метастаз рака предстательной железы в стенку желудка: клинический случай и обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5795-337X</contrib-id><name-alternatives><name xml:lang="en"><surname>Prokhorov</surname><given-names>D. G.</given-names></name><name xml:lang="ru"><surname>Прохоров</surname><given-names>Д. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>prokhor_off@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0589-7999</contrib-id><name-alternatives><name xml:lang="en"><surname>Shkolnik</surname><given-names>M. I.</given-names></name><name xml:lang="ru"><surname>Школьник</surname><given-names>М. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shkolnik_phd@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2195-2401</contrib-id><name-alternatives><name xml:lang="en"><surname>Dolbov</surname><given-names>A. L.</given-names></name><name xml:lang="ru"><surname>Долбов</surname><given-names>А. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>art.dolbov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5860-9076</contrib-id><name-alternatives><name xml:lang="en"><surname>Bogomolov</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Богомолов</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>urologbogomolov@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Research Center for Radiology and Surgical Technologies named after A. M. Granov, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научный центр радиологии и хирургических технологий им. акад. А. М. Гранова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">70 Leningradskaya St., Pesochnyy, Saint Petersburg 197758</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научный центр радиологии и хирургических технологий им. акад. А. М. Гранова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-18" publication-format="electronic"><day>18</day><month>12</month><year>2025</year></pub-date><volume>21</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>136</fpage><lpage>141</lpage><history><date date-type="received" iso-8601-date="2025-05-22"><day>22</day><month>05</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-24"><day>24</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Prokhorov D.G., Shkolnik M.I., Dolbov A.L., Bogomolov O.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Прохоров Д.Г., Школьник М.И., Долбов А.Л., Богомолов О.А.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Prokhorov D.G., Shkolnik M.I., Dolbov A.L., Bogomolov O.A.</copyright-holder><copyright-holder xml:lang="ru">Прохоров Д.Г., Школьник М.И., Долбов А.Л., Богомолов О.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://oncourology.eco-vector.com/oncur/article/view/1947">https://oncourology.eco-vector.com/oncur/article/view/1947</self-uri><abstract xml:lang="en"><p>Prostate cancer (PCa) ranks first in cancer morbidity among the male population of Russia and third in cancer-related mortality among men. The presence of metastatic disease significantly worsens prognosis. PCa most frequently metastasizes to bone and regional lymph nodes. Gastric wall involvement in combination with peritoneal carcinomatosis is extremely rare, partly due to the limited sensitivity of conventional diagnostic modalities in patients with PCa.</p> <p>We present the first case in the Russian literature of asymptomatic gastric wall metastasis from PCa with concurrent peritoneal carcinomatosis, diagnosed 15 years after the initial diagnosis. A notable feature of this case is the absence of bone or lymph node metastases, which are the typical sites of dissemination, suggesting the potential for secondary lesions to occur in unusual locations.</p> <p>The metastatic lesion and carcinomatosis were identified by using positron emission tomography combined with computed tomography with prostate-specific membrane antigen and subsequently confirmed histologically. This case illustrates the importance of high-tech diagnostic methods for the detection of atypical metastases.</p></abstract><trans-abstract xml:lang="ru"><p>Рак предстательной железы (РПЖ) занимает 1-е место в структуре онкологической заболеваемости мужского населения России и 3-е место в структуре смертности мужчин от злокачественных новообразований. Наличие метастатического процесса существенно отягощает течение заболевания. Чаще всего РПЖ метастазирует в кости и лимфатические узлы. Метастатическое поражение стенки желудка в сочетании с карциноматозом встречается редко, отчасти вследствие низкой чувствительности конвенциальных методов обследования пациентов с РПЖ.</p> <p>В статье представлен первый в отечественной литературе клинический случай бессимптомного метастаза РПЖ в стенку желудка с явлениями карциноматоза брюшины, выявленного через 15 лет после установления первичного диагноза. Особенность случая заключается в отсутствии поражения костей и лимфатических узлов – типичных мест метастазирования, что указывает на возможность развития вторичных очагов в других, нетипичных локализациях. Метастатический очаг и карциноматоз обнаружены методом позитронно-эмиссионной томографии, совмещенной с компьютерной томографией, с простатическим специфическим мембранным антигеном и подтверждены гистологически, что иллюстрирует важность применения высокотехнологичных методов диагностики для выявления нетипичных метастазов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>prostate cancer</kwd><kwd>prostate cancer metastasis</kwd><kwd>positron emission tomography combined with computed tomography</kwd><kwd>prostate-specific membrane antigen</kwd><kwd>gastric metastasis of prostate cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак предстательной железы</kwd><kwd>метастаз рака предстательной железы</kwd><kwd>позитронно-эмиссионная томография, совмещенная с компьютерной томографией</kwd><kwd>простатический специфический мембранный антиген</kwd><kwd>метастаз рака предстательной железы в желудок</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Malignant neoplasms in Russia in 2023 (morbidity and mortality). Eds.: А.D. Kaprin, V.V. Starinskiy, A.O. Shakhzadova. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITS radiologii” Minzdrava Rossii, 2024. 276 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2023 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, О.В. Шахзадовой. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2024. 276 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Siegel R., Giaquinto A., Jemal A. Cancer statistics, 2024. CA Cancer J Clin 2024;74(1):12–49. DOI: 10.3322/caac.21820</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Brawn P. Histologic features of metastatic prostate cancer. Hum Pathol 1992;23(3):267–72. DOI: 10.1016/0046-8177(92)90107-e</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Drake C.G. Visceral metastases and prostate cancer treatment: ‘die hard,’ ‘tough neighborhoods,’ or ‘evil humors’? Oncology 2014;28(11):974–80.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Bubendorf L., Schopfer A., Wagner U. et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 2000;31(5):578–83. DOI: 10.1053/hp.2000.669</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Pezaro C., Omlin A., Lorente D. et al. Visceral disease in castration-resistant prostate cancer. Eur Urol 2014;65:270–3. DOI: 10.1016/j.eururo.2013.10.055</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Petrakis D., Pentheroudakis G., Kamina S. et al. An unusual presentation of a patient with advanced prostate cancer, massive ascites and peritoneal metastasis: case report and literature review. J Adv Res 2015;6(3):517–21. DOI: 10.1016/j.jare.2014.05.002</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Green L.K. Hematogenous metastases to the stomach. A review of 67 cases. Cancer 1990;65(7):1596–600. DOI: 10.1002/1097-0142(19900401)65:7&lt;1596::aid-cncr2820650724&gt;3.0.co;2-5</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Rapoport A.H., Omenn G.S. Dermatomyositis and malignant effusions: rare manifestations of carcinoma of the prostate. J Urol 1968;100(2):183–7. DOI: 10.1016/s0022-5347(17)62502-3</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Moshref L., Abidullah M., Czaykowski P. et al. Prostate cancer metastasis to stomach: a case report and review of literature. Curr Oncol 2023;30(4):3901–14. DOI: 10.3390/curroncol30040295</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Inagaki C., Suzuki T., Kitagawa Y. et al. A case report of prostate cancer metastasis to the stomach resembling undifferentiated-type early gastric cancer. BMC Gastroenterol 2017;17:93. DOI: 10.1186/s12876-017-0655-0</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Barbosa F.G., Queiroz M.A., Nunes R.F. et al. Revisiting prostate cancer recurrence with PSMA PET: atlas of typical and atypical patterns of spread. Radiographics 2019;39(1):186–212. DOI: 10.1148/rg.2019180079</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Tanaka T., Yang M., Froemming A.T. et al. Current imaging techniques for and imaging spectrum of prostate cancer recurrence and metastasis: a pictorial review. Radiographics 2020;40(3):709–26. DOI: 10.1148/rg.2020190121</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Delchambre E., Rysselinck S., Pairet G. et al. Isolated peritoneal carcinomatosis in prostate cancer: from a successful hormonal management to a review of the literature. Future Sci OA 2021;7(6):FSO707. DOI: 10.2144/fsoa-2021-0009</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Bhandari V., Pant S. Carcinoma prostate with gastric metastasis: a rare case report. J Cancer Res Ther 2015;11(3):659. DOI: 10.4103/0973-1482.139389</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Hong K.P., Lee S.J., Hong G.S. et al. Prostate cancer metastasis to the stomach. Korean J Urol 2010;51(6):431. DOI: 10.4111/kju.2010.51.6.431</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Christoph F., Grünbaum M., Wolkers F. et al. Prostate cancer metastatic to the stomach. Urology 2004;63(4):778–9. DOI: 10.1016/j.urology.2003.12.009</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Bilici A., Dikilitas M., Eryilmaz O.T. et al. Stomach metastasis in a patient with prostate cancer 4 years after the initial diagnosis: a case report and a literature review. Case Rep Oncol Med 2012;2012:292140. DOI: 10.1155/2012/292140</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Soe A.M., Bordia S., Xiao P.Q. et al. A rare presentation of metastasis of prostate adenocarcinoma to the stomach and rectum. J Gastric Cancer 2014;14(4):271–4. DOI: 10.5230/jgc.2014.14.4.271</mixed-citation></ref></ref-list></back></article>
