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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Cancer Urology</journal-id><journal-title-group><journal-title xml:lang="en">Cancer Urology</journal-title><trans-title-group xml:lang="ru"><trans-title>Онкоурология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9776</issn><issn publication-format="electronic">1996-1812</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1983</article-id><article-id pub-id-type="doi">10.17650/1726-9776-2025-21-3-148-156</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Renal cell carcinoma in patients with nephrolithiasis: systematic review</article-title><trans-title-group xml:lang="ru"><trans-title>Точки соприкосновения почечно-клеточного рака и нефролитиаза: систематический обзор</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2767-7153</contrib-id><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>tatianalelyavina@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9935-0243</contrib-id><name-alternatives><name xml:lang="en"><surname>Guseynov</surname><given-names>R. G.</given-names></name><name xml:lang="ru"><surname>Гусейнов</surname><given-names>Р. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4780-8720</contrib-id><name-alternatives><name xml:lang="en"><surname>Isakova-Sivak</surname><given-names>I. N.</given-names></name><name xml:lang="ru"><surname>Исакова-Сивак</surname><given-names>И. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4064-5033</contrib-id><name-alternatives><name xml:lang="en"><surname>Sivak</surname><given-names>K. V.</given-names></name><name xml:lang="ru"><surname>Сивак</surname><given-names>К. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6664-2861</contrib-id><name-alternatives><name xml:lang="en"><surname>Skryabin</surname><given-names>O. N.</given-names></name><name xml:lang="ru"><surname>Скрябин</surname><given-names>О. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2841-0370</contrib-id><name-alternatives><name xml:lang="en"><surname>Gorbacheva</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Горбачева</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4331-028X</contrib-id><name-alternatives><name xml:lang="en"><surname>Bunenkov</surname><given-names>N. S.</given-names></name><name xml:lang="ru"><surname>Буненков</surname><given-names>Н. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>bunenkov2006@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6294-6182</contrib-id><name-alternatives><name xml:lang="en"><surname>Malyshev</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Малышев</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6436-3860</contrib-id><name-alternatives><name xml:lang="en"><surname>Beshtoev</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Бештоев</surname><given-names>А. Х.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@lucaclinic.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6796-4064</contrib-id><name-alternatives><name xml:lang="en"><surname>Lelyavina</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Лелявина</surname><given-names>T. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>tatianalelyavina@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">St. Luka’s Clinical Hospital</institution></aff><aff><institution xml:lang="ru">СПб ГБУЗ Клиническая больница Святителя Луки</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Saint Petersburg Medical and Social Institute</institution></aff><aff><institution xml:lang="ru">ЧОУ ВО «Санкт-Петербургский медико-социальный институт»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Saint Petersburg State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Санкт-Петербургский государственный университет»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">A.A. Smorodintsev Research Institute of Influenza, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Научно-исследовательский институт гриппа им. А. А. Смородинцева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">V.A. Almazov National Medical Research Centre, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-18" publication-format="electronic"><day>18</day><month>12</month><year>2025</year></pub-date><volume>21</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>148</fpage><lpage>156</lpage><history><date date-type="received" iso-8601-date="2025-10-20"><day>20</day><month>10</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-11-12"><day>12</day><month>11</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Popov S.V., Guseynov R.G., Isakova-Sivak I.N., Sivak K.V., Skryabin O.N., Gorbacheva I.A., Bunenkov N.S., Malyshev E.A., Beshtoev A.K., Lelyavina T.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Попов С.В., Гусейнов Р.Г., Исакова-Сивак И.Н., Сивак К.В., Скрябин О.Н., Горбачева И.А., Буненков Н.С., Малышев Е.А., Бештоев А.Х., Лелявина T.А.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Popov S.V., Guseynov R.G., Isakova-Sivak I.N., Sivak K.V., Skryabin O.N., Gorbacheva I.A., Bunenkov N.S., Malyshev E.A., Beshtoev A.K., Lelyavina T.A.</copyright-holder><copyright-holder xml:lang="ru">Попов С.В., Гусейнов Р.Г., Исакова-Сивак И.Н., Сивак К.В., Скрябин О.Н., Горбачева И.А., Буненков Н.С., Малышев Е.А., Бештоев А.Х., Лелявина T.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://oncourology.eco-vector.com/oncur/article/view/1983">https://oncourology.eco-vector.com/oncur/article/view/1983</self-uri><abstract xml:lang="en"><p>This review examines literature data on the possible relationship between development of kidney cancer and long-term nephrolithiasis. Results of research on the epidemiology of the diseases in question are presented, key take-aways and conclusions of the specialists who study this problem are reflected, current state of the issues of kidney stones-associated carcinogenesis of malignant kidney lesions is shown.</p></abstract><trans-abstract xml:lang="ru"><p>В предлагаемом обзоре рассмотрены данные литературы, касающиеся возможной взаимосвязи между развитием рака почки и многолетней мочекаменной болезнью. Представлены результаты исследований эпидемиологии рассматриваемых заболеваний, отражены выводы и заключения специалистов, изучавших эту проблему, показано современное состояние вопросов канцерогенеза злокачественных поражений почки, ассоциированного с мочекаменной болезнью.</p></trans-abstract><kwd-group xml:lang="en"><kwd>kidney cancer</kwd><kwd>urolithiasis</kwd><kwd>kidney stones-associated carcinogenesis of kidney cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак почки</kwd><kwd>мочекаменная болезнь</kwd><kwd>канцерогенез рака почки, ассоциированный с мочекаменной болезнью</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Комитет по здравоохранению Санкт-Петербурга</institution></institution-wrap><institution-wrap><institution xml:lang="en">St. Petersburg Health Committee</institution></institution-wrap></funding-source></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Abufaraj M., Xu T., Cao C. et al. 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